This document presents the National COVID-19 Vaccine Campaign Plan (the Plan) as part of Operation COVID Shield, announced by Prime Minister Scott Morrison on 8 June 2021. Implementation of the Plan will be coordinated by the National COVID Vaccine Taskforce (NCVTF) and led by Lieutenant General (LTGEN) John Frewen as the Coordinator General. The NCVTF’s goals are to ensure public confidence in the vaccine rollout and to ensure that as many Australians as possible are vaccinated as early as possible. The Plan proposes a National cooperative approach which builds on both Australia’s COVID-19 Vaccine and Treatment Strategy, and Australia’s COVID-19 Vaccine National Rollout Strategy to ensure Australia’s vaccination goals are achieved. The Plan anticipates a levelling of uptake toward the end of the year as most willing people will have already been vaccinated. The Plan accounts for foreseen program risks and presents options to mitigate them including modelling of multiple scenarios, with a view to contingency planning and improving preparation for potential challenges such as low workforce capacity in certain states and territories, and reduced or new vaccine supply. The Plan also accounts for the need to continually assess the performance of the rollout and respond to changing circumstances, including the dynamic reallocation of supply, personal protective equipment (PPE), and consumables.